ABSTRACT
It is well known that the development and progression of prostate cancer are androgen dependent and the action of androgen in prostate is mediated by androgen receptor. But the role of androgen receptor in the development and progression of prostate cancer have been not defined. Recently, the development of mmunohistochemical assay has provided new opportunities for study of androgen receptor. Immunohistochemical stainings were performed for 3 cases of normal prostate, 17 of BPH and 17 of prostate cancer. Specimens were obtained from cystoprostatectomy of bladder cancer patients(normal prostate), suprapubic prostatectomy and transurethral resection of prostate(BPH) and radical prostatectomy and prostate biopsies(prostate cancer). Androgen receptors were stained predominantly in nucleus of glandular cell. Normal prostates were stained homogeneously and heterogeneous staining of androgen receptor was more in pro- state cancer than BPH and in high grade(Gleason`s score 5-10) than low grade (Gleason`s score 2-4). Total intensity score of normal prostate, BPH and prostate cancer were 196.6+/-20.8, 202. 4+/-54.3 and 180.6+/-47.0 respectively and cancer tissues were stained the least intensely, but statistically not significant(P > 0.05). Staining of prostate cancer revealed less intensity in high grade(161.8+/-36.8, P < 0.05) than low grade(215.0+/-46.8). It is postulated that the distribution of androgen receptor in the prostate cancer was correlated with cellular differentiation and also it is suggesting that androgen receptor is closely related with development of androgen independent cancer.
Subject(s)
Prostate , Prostatectomy , Prostatic Neoplasms , Receptors, Androgen , Urinary Bladder NeoplasmsABSTRACT
The urachus lies between the peritoneum and transversalis fascia and extend from the anterior dome of the bladder toward the umbilicus. The urachal sinus is opened at the umbilicus superiority and not connected with the bladder. This may become symptomatic at any age with an infected discharge. We experienced a case of infected urachal sinus in a 21 years old girl, so we report this case with review of literatures.
Subject(s)
Female , Humans , Young Adult , Fascia , Peritoneum , Umbilicus , Urachus , Urinary BladderABSTRACT
Augmentin is a formulation of amoxycillin trihydrate and potassium clavulanate, a fused beta-lactam molecule produced by the fermentation of straptomyces clavuligerus. Most clinically important resistance is due to the production by bacteria of antibiotic destroying enzymes. In the case of penicillins and cephalospolins these enzymes are termed beta-lactamse as they destroy the beta-lactam ring of these antibiotics completely inactivating them. The presence of clavulanic acid extends the spectrum of amoxycillin to include beta-lactamse producing strains of common pathogens such as Staphylococcus, H influenza, E. coli, Neisseria spp, Proteus spp, Salmonella and Shigella. On clinical study of Augmenting in the field of Genitourinary tract infection cases. We selected randomly 30 patients, 20 males and 10 females, age from 21 to 71, in the period from October, 1985 to February, 1986. Among the total 30 patients, 15 were uncomplicated urinary tract infection and 15 were complicated urinary tract infection. Of the 15 patients with uncomplicated urinary tract infection, 14 patients had not bacteriuria after therapy and 1 patient was not changed. The clinical efficacy rate was 93.4%. Of the 4 patients with persistent infection, 2 patients had resistant P. aeruginosa, and 2 patients had S marcescens persistantly. The clinical efficacy rate was 73.4%. In 2 cases, mild diarrhea was developed, but medication was not stopped. The liver and renal function were normal range before and after treatment.
Subject(s)
Female , Humans , Male , Amoxicillin , Amoxicillin-Potassium Clavulanate Combination , Anti-Bacterial Agents , Bacteria , Bacteriuria , beta-Lactams , Clavulanic Acid , Diarrhea , Fermentation , Influenza, Human , Liver , Neisseria , Penicillins , Proteus , Reference Values , Salmonella , Shigella , Staphylococcus , Urinary Tract InfectionsABSTRACT
Urinary obstruction leads to hydronephrosis, distention of renal pelvis and calices with urine accompanying atrophy of renal parenchyma. Especially longstanding incomplete obstruction may lead to giant hydronephrosis and terminate in destruction of the organ We experienced a case of giant hydronephrosis combined with ureteral stone in 50 year old man, so we report this case with review of literatures.
Subject(s)
Humans , Middle Aged , Atrophy , Hydronephrosis , Kidney Pelvis , UreterABSTRACT
Leiomyoma is benign tumor, which usually occurs at the smooth muscle of gastrointestinal tract and uterus but leiomyoma on the penis is very. rare neoplasm. We experienced a case of leiomyoma on the penis in a 17 year old man, so we report this case with review of literatures.